Plasma Androgens and the Presence and Course of Depression in a Large Cohort of Men

May 2021 in “ Psychoneuroendocrinology ”

Anouk E. de Wit, Erik J. Giltay, Marrit K. de Boer, Willem A. Nolen, Fokko J. Bosker, Brenda W.J.H. Penninx, Robert A. Schoevers

plasma androgens androstenedione DHEAS 5α-DHT dehydroepiandrosterone sulfate dihydrotestosterone

Studysummary This study suggests that circulating androgens produced by the testes have limited clinical relevance to major depressive disorder in adult men, but certain androgens may be linked to specific MDD symptoms.

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The study investigated the relationship between plasma androgens and major depressive disorder (MDD) in a large cohort of men. It concluded that circulating androgens synthesized by the testes were of limited clinical relevance to MDD in adult men. However, specific androgens such as androstenedione, DHEAS, and 5α-DHT might be associated with certain individual symptoms of MDD.

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research LC-MS/MS-Based Method for Long-Term Steroid Profiling in Human Scalp Hair

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This study introduced a validated LC-MS/MS-based method for profiling long-term steroid concentrations in human scalp hair, offering potential applications in endocrinology research.