Pharmacokinetic Interaction of Finasteride With Tamsulosin Hydrochloride: An Open-Label, Randomized, Three-Period Crossover Study in Healthy Chinese Male Volunteers

    February 2015 in “ Clinical Therapeutics ”
    Nan-Nan Chu, Hong-Rong Xu, Guoqin Wang, Jiangdian Wang, Wei-Li Chen, Fei Yuan, Mengjie Yang, Xue-Ning Li
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    TLDR Finasteride and tamsulosin hydrochloride can be safely taken together without significant interaction.
    This study investigated the potential pharmacokinetic interaction between finasteride and tamsulosin hydrochloride in healthy Chinese male volunteers. The study found that co-administration of the two drugs did not lead to a clinically significant PK drug-drug interaction, both after a single dose and at steady state. The study also found that the co-administration of the two drugs was safe and well-tolerated. However, the study had a small sample size of only 12 participants, which limits the generalizability of the findings.
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