Phytochemical Profiling, Antioxidant Activity, and In Silico Analyses of Sterculia Villosa and Vernonia Patula

    June 2022 in “ Evidence-based Complementary and Alternative Medicine ”
    Chadni Lyzu, Saikat Mitra, Kahkashan Perveen, Zidan Khan, Abu Montakim Tareq, Najat A. Bukhari, Fohad Mabood Husain, Evena Parvin Lipy, Dipa Islam, Mahmuda Hakim, Talha Bin Emran, Marjan Ganjali Dashti
    Studysummary This study reported that both Sterculia villosa bark and Vernonia patula plant extracts showed concentration-dependent antioxidant activities, with Vernonia patula demonstrating a stronger effect. Our plain-language summary of this paper — not a Tressless recommendation.
    The study evaluated the chemical profiles and antioxidant activities of methanolic extracts from Sterculia villosa bark (MESV) and Vernonia patula whole plant (MEVP). Using GC-MS, 52 compounds were identified in MESV and 33 in MEVP. Both extracts demonstrated concentration-dependent antioxidant activities, with IC50 values of 305.30 μg/mL for MEVP and 555.44 μg/mL for MESV, compared to 36.32 μg/mL for ascorbic acid. MESV had total flavonoid and phenolic contents of 81.44 mg QE/g and 62.58 mg GAE/g, while MEVP had 291.31 mg QE/g and 58.99 mg GAE/g. Molecular docking and ADME/toxicological assessments suggested that S. villosa and V. patula could be promising candidates for further research into oxidative stress.
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