Development of Phage-Containing Hydrogel for Treating Enterococcus Faecalis-Infected Wounds

The study developed a phage-containing hydrogel using sodium alginate, carboxymethyl cellulose, and hyaluronic acid to treat Enterococcus faecalis-infected wounds, particularly those resistant to vancomycin. The hydrogel demonstrated significant antibacterial activity, reducing bacterial growth in vitro and in vivo. In tests on mice, the hydrogel reduced bacterial load and enhanced wound healing, with improved epithelialization and tissue restoration. The hydrogel maintained stability for four weeks, offering a promising method for controlled phage release and improved clinical outcomes in treating infected wounds. The study highlights the hydrogel's potential as an effective wound care therapy, addressing antibiotic resistance challenges and promoting tissue regeneration.