The Effects of Perinatal Androgen Deprivation on Body Weight and Spatial Working Memory in Male Rats

April 2015 in “ The FASEB Journal ”

Binita Shah, Alicia Yn, Talha Khan, Dane Fickes, Pakou Vang, KumHwa Jeong, Faeeq Yousaf, George Taylor, C. Gopalan, Claude J. Gaebelein

androgen deprivation flutamide androgen receptors estrogen

TLDR Blocking male hormones in baby rats improved memory and increased weight.

The study investigated the effects of perinatal androgen deprivation on spatial working memory (SWM) and body weight in male Long-Evans rats. A total of 37 rats were divided into two groups, with one group receiving flutamide to block androgen receptors during the perinatal period. On postnatal day 65, these groups were further divided into subgroups receiving finasteride, letrozole, or a vehicle. The results showed that rats treated with flutamide and finasteride or vehicle exhibited improved SWM, as evidenced by greater choice accuracy in a Radial Arm Maze Test. Additionally, the flutamide-treated group had increased body weight and higher serum estrogen levels compared to the control group, suggesting a link between body weight, memory, and estrogen levels.

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