The Effects of Perinatal Androgen Deprivation on Body Weight and Spatial Working Memory in Male Rats

    April 2015 in “ The FASEB Journal ”
    Binita Shah, Alicia Yn, Talha Khan, Dane Fickes, Pakou Vang, KumHwa Jeong, Faeeq Yousaf, George Taylor, C. Gopalan, Claude J. Gaebelein
    TLDR Blocking male hormones in baby rats improved memory and increased weight.
    The study investigated the effects of perinatal androgen deprivation on spatial working memory (SWM) and body weight in male Long-Evans rats (N=37) by administering flutamide to block androgen receptors during the perinatal period. The results indicated that rats in the flutamide-treated group (Group 1) exhibited improved SWM, as evidenced by greater choice accuracy in a Radial Arm Maze Test, and increased body weight compared to the control group (Group 2). Additionally, Group 1 had higher serum estrogen levels, suggesting a link between elevated estrogen, enhanced memory performance, and increased body weight.
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