The Effects of Perinatal Androgen Deprivation on Locomotor Activity in Male Rats

April 2015 in “ The FASEB Journal ”

KumHwa Jeong, Alicia Yn, Talha Khan, Dane Fickes, Pakou Vang, Faeeq Yousaf, Binita Shah, George T. Taylor, C. Gopalan

androgen deprivation flutamide androgen receptors finasteride letrozole estrogen levels FLU

TLDR Blocking androgens in male rats increased estrogen and made them more active.

The study investigated the effects of perinatal androgen deprivation on estrogen levels and locomotor activity in male Long-Evans rats. A total of 37 rats were divided into two groups, with one group receiving flutamide (FLU) to block androgen receptors during the perinatal period. On postnatal day 65, these groups were further divided into subgroups receiving finasteride, letrozole, or a vehicle. The results showed that rats treated with FLU had higher serum estrogen levels and exhibited increased locomotor activity, spending more time in the center of an open field. This suggested that perinatal androgen deprivation led to elevated estrogen levels, which may have influenced the rats' exploratory behavior.

View this study on doi.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Protac degradation of the androgen receptor in mice shows good efficacy and no systemic drug could be found

in Research/Science 47 upvotes 2 years ago

The efficacy of degrading the androgen receptor through dermal application in DP cells, a delivery system for topical drugs that involves dissolving microneedles, and rosemary oil as an alternative anti-androgen.

community I Get Side-Effects from Anti-Androgens

in Finasteride/Dutasteride 7 upvotes 5 years ago

Someone looking for solutions to their hair loss, who has tried and failed to tolerate anti-androgen treatments such as finasteride, CB-03-01, RU58841, and Eucapil. The user is seeking advice and understanding of their extreme sensitivity to these treatments.

community Topical Dutasteride - Non-Hormonal, Side Effect Free 5ARI?

in Treatments 451 upvotes 1 year ago

Topical dutasteride is suggested as a low side-effect treatment for hair loss, with a proposed dose of 0.025% 1ml/day. It is considered better than finasteride due to its even inhibition of DHT isoforms and lower systemic absorption.

community Can finasteride affect on your muscle and other things?

in Finasteride/Dutasteride 1 upvotes 1 year ago

The conversation discusses using finasteride topically for hair loss and concerns about potential side effects like feminization and impact on muscle growth. One person shared their experience with finasteride, indicating it increased testosterone and did not prevent them from gaining muscle or strength.

community For those on TRT and suffer from a more aggressive type of (AGA) hairloss, what are your hair safe protocols?

in Chat 6 upvotes 2 years ago

People on testosterone replacement therapy (TRT) with aggressive androgenetic alopecia (AGA) discuss using Dutasteride or Finasteride, sometimes combined with topical treatments like RU58841 or CB-03-01 (Breezula), to prevent hair loss. Concerns about side effects and costs of certain treatments are mentioned, with one individual sharing their experience of slowed hair loss using Finasteride alone.

community Is there a consensus on RU these days? Pyril turned out to be a bust right?

in Research/Science 17 upvotes 1 year ago

The conversation discusses the effectiveness and safety of hair loss treatments, specifically RU58841 and Pyrilutimide (Pyril), with users sharing that Pyril was no more effective than a placebo and expressing concerns about the safety of RU58841 based on personal experiences and the lack of pharmaceutical interest.

Similar Research

5 / 1000+ results

research Organizational Effects of Estrogens and Androgens on Estrogen and Androgen Receptor Expression in Pituitary and Adrenal Glands in Adult Male and Female Rats

1 citations , June 2022 in “Frontiers in Neuroanatomy”

Early hormones shape sex-specific differences in rat glands.

research Is Dehydroepiandrosterone a Hormone?

403 citations , November 2005 in “Journal of Endocrinology”

Dehydroepiandrosterone (DHEA) is a prohormone important for producing sex steroids and has potential health benefits.

Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

research Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

20 citations , June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery”

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

research Enhanced Ex Vivo Skin Retention of Bicalutamide Using a Nano-in-Micro Composite: Drug-Loaded Lipid Vesicles in a Dissolving Microarray Patch

April 2025 in “European Journal of Pharmaceutics and Biopharmaceutics”

The new drug delivery system improves bicalutamide skin retention for better treatment of hair loss.

research Safety of 5α-Reductase Inhibitors and Spironolactone in Breast Cancer Patients Receiving Endocrine Therapies

22 citations , November 2018 in “Breast Cancer Research and Treatment”

The medications 5α-reductase inhibitors and spironolactone are generally safe for breast cancer patients on endocrine therapies and do not significantly increase breast cancer risk.