Perifollicular Fibrosis: Pathogenetic Role in Androgenetic Alopecia
June 2006
in “Biological & Pharmaceutical Bulletin”
TLDR Androgen hormones cause hair follicle scarring in hair loss, and finasteride helps reduce it.
This study investigated the role of perifollicular fibrosis in androgenetic alopecia (AGA). The researchers found that androgen hormones stimulate the production of collagen from follicular dermal papilla cells, leading to perifollicular fibrosis in AGA. Finasteride was found to reduce this fibrosis. The study suggests that perifollicular fibrosis may play a pathogenetic role in AGA, and that finasteride may inhibit this process.
View this study on jstage.jst.go.jp →
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research Balding hair follicle dermal papilla cells contain higher levels of androgen receptors than those from non-balding scalp
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research ANDROGEN METABOLISM AS IT AFFECTS HAIR GROWTH IN ANDROGENETIC ALOPECIA
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research Androgenetic alopecia: An autosomal dominant disorder
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research Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia
Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.
research Male Pattern Alopecia A Histopathologic and Histochemical Study
Male pattern baldness involves smaller hair follicles, larger oil glands, and other tissue changes, but not major blood supply issues.
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