Paradigm Shift in the Concept of Hormonal Milieu of Prostate Cancer

November 2011 in “ InTech eBooks ”

Tsutomu Nishiyama

androgens testosterone dihydrotestosterone DHT androgen metabolism adrenal androgens steroid precursors

TLDR Prostate cancer risk is not linked to blood testosterone levels.

A study involving 3,886 prostate cancer cases and 6,438 matched controls found no association between circulating androgens and the risk of prostate cancer, regardless of tumor stage or grade. This indicated that prostate cancer risk and tumor aggressiveness were not related to serum levels of total and free testosterone. However, the findings did not negate the role of androgens in prostate cancer but highlighted the importance of androgen metabolism within the prostate. The exact contribution of testosterone and dihydrotestosterone (DHT) from adrenal androgens or other steroid precursors to the prostate remained unclear.

View this study on intechopen.com →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research 5α-Reductase Isozymes and Androgen Actions in the Prostate

93 citations, February 2009 in “Annals of the New York Academy of Sciences”

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

research Androgen Biosynthetic Pathways in the Human Prostate

160 citations, April 2008 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

Related Community Posts Join

6 / 1000+ results

community It’s over. NOTHING has worked.

in Chat 95 upvotes 2 years ago

A user who has been trying various treatments for hair loss for four years, with no success. Suggestions include use of minoxidil, finasteride, RU58841, microneedling, supplements and multivitamins, lifestyle changes, scalp biopsy, and SMP.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 667 upvotes 2 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 2 months ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 8 months ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

Similar Research

6 / 1000+ results

research Androgen Effects in Mammals

7 citations, January 2003 in “Elsevier eBooks”

Testosterone is crucial for development, growth, and various body functions in mammals.

research Markers of Peripheral Androgen Action In Vivo and In Vitro

4 citations, October 1988 in “Clinics in Dermatology”

Dihydrotestosterone (DHT) is crucial for conditions like male-pattern baldness and acne, and measuring a byproduct, androstanediol glucuronide, is a better way to assess DHT's effects than DHT blood levels.

research Androgen Actions on the Human Hair Follicle: Perspectives

115 citations, September 2012 in “Experimental Dermatology”

Androgens have complex effects on hair growth, promoting it in some areas but causing hair loss in others, and our understanding of this is still evolving.

Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

research Hydroxysteroid Dehydrogenase (17β-HSD3, 17β-HSD5, and 3α-HSD3) Inhibitors: Extragonadal Regulation of Intracellular Sex Steroid Hormone Levels

20 citations, June 2007 in “Recent Patents on Endocrine, Metabolic & Immune Drug Discovery”

Certain inhibitors can potentially treat prostate cancer and other hormone-dependent conditions by controlling sex hormone levels in cells.

research What Does the Research Say About Androgen Use and Cerebrovascular Events?

5 citations, May 2018 in “Therapeutic advances in drug safety”

Androgen use may increase the risk of stroke, but more research is needed.

research Antiandrogens and Androgen Inhibitors in Dermatologic Treatments

November 2020 in “Elsevier eBooks”

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.