Paradigm Shift in the Concept of Hormonal Milieu of Prostate Cancer

November 2011 in “ InTech eBooks ”

Tsutomu Nishiyama

androgens testosterone dihydrotestosterone DHT androgen metabolism adrenal androgens steroid precursors

Studysummary This study found no association between circulating androgens and prostate cancer risk, underscoring the complex role of androgen metabolism in the prostate.

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A study involving 3,886 prostate cancer cases and 6,438 matched controls found no association between circulating androgens and the risk of prostate cancer, regardless of tumor stage or grade. This indicated that prostate cancer risk and tumor aggressiveness were not related to serum levels of total and free testosterone. However, the findings did not negate the role of androgens in prostate cancer but highlighted the importance of androgen metabolism within the prostate. The exact contribution of testosterone and dihydrotestosterone (DHT) from adrenal androgens or other steroid precursors to the prostate remained unclear.

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research 5α-Reductase Isozymes and Androgen Actions in the Prostate

93 citations , February 2009 in “Annals of the New York Academy of Sciences”

This review describes the roles of 5α-reductase isozymes in prostate development and pathology and reports no new clinical results.

research Androgen Biosynthetic Pathways in the Human Prostate

160 citations , April 2008 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

This review outlines the complexities of understanding DHT biosynthesis and metabolism in the human prostate and reports no new findings, emphasizing the need for further research into the pathways involved.