Paradigm Shift in the Concept of Hormonal Milieu of Prostate Cancer

November 2011 in “ InTech eBooks ”

Tsutomu Nishiyama

androgens testosterone dihydrotestosterone DHT androgen metabolism adrenal androgens steroid precursors

TLDR Prostate cancer risk is not linked to blood testosterone levels.

A study involving 3,886 prostate cancer cases and 6,438 matched controls found no association between circulating androgens and the risk of prostate cancer, regardless of tumor stage or grade. This indicated that prostate cancer risk and tumor aggressiveness were not related to serum levels of total and free testosterone. However, the findings did not negate the role of androgens in prostate cancer but highlighted the importance of androgen metabolism within the prostate. The exact contribution of testosterone and dihydrotestosterone (DHT) from adrenal androgens or other steroid precursors to the prostate remained unclear.

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Research cited in this study

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research 5α-Reductase Isozymes and Androgen Actions in the Prostate

93 citations, February 2009 in “Annals of the New York Academy of Sciences”

5α‐reductase isozymes are crucial for prostate development and health, and targeting them can help prevent and treat prostate issues.

research Androgen Biosynthetic Pathways in the Human Prostate

160 citations, April 2008 in “Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism”

DHT in the human prostate is produced through multiple pathways, not just from testosterone.

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community It’s over. NOTHING has worked.

in Chat 95 upvotes 2 years ago

A user who has been trying various treatments for hair loss for four years, with no success. Suggestions include use of minoxidil, finasteride, RU58841, microneedling, supplements and multivitamins, lifestyle changes, scalp biopsy, and SMP.

community The Real Cause Of Androgenetic Alopecia

in Research/Science 674 upvotes 3 months ago

Androgenetic alopecia is caused by DHT affecting hair growth. Finasteride and minoxidil are used to manage hair loss by blocking DHT and promoting hair growth.

Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 768 upvotes 3 months ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

in Research 830 upvotes 5 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community Does finasteride/dutasteride reverse aging?

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Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

community Why is it that low testosterone causes hair loss as well? How can I be balding?

in Chat 158 upvotes 9 months ago

The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

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