50 citations
,
November 2021 in “Viruses” This study observed that in vitro exposure to dihydrotestosterone worsened COVID-19 spike protein-induced endothelial injury, while spironolactone showed potential in reducing this effect, suggesting a rationale for further evaluation in treating COVID-19.
41 citations
,
February 2021 in “Cureus” In this study, Proxalutamide significantly increased the rate of viral clearance and reduced clinical remission time in patients with mild to moderate COVID-19 compared to placebo.
41 citations
,
February 2021 in “Cureus” This study found that in males with mild COVID-19, treatment with dutasteride, along with standard therapy, may reduce viral shedding and inflammation compared to placebo.
3 citations
,
December 2020 in “Problemy e̊ndokrinologii” This review discusses androgen and antiandrogen studies in COVID-19, noting potential impacts on disease severity and suggesting the need for more data on their effectiveness and safety.
36 citations
,
November 2020 in “Journal of The European Academy of Dermatology and Venereology” This study found that 5-alpha-reductase inhibitors were associated with a reduced frequency of COVID-19 symptoms in males with androgenetic alopecia.
27 citations
,
October 2020 in “Experimental Dermatology” This study found that both extensive grey hair and alopecia were independently associated with increased COVID-19 severity among survey respondents in Brazil.
12 citations
,
August 2020 in “Annals of Oncology” This study found that androgen deprivation therapy in prostate cancer patients was associated with fewer SARS-CoV-2 infections but did not reduce COVID-19 disease severity or hospitalizations.
29 citations
,
July 2020 in “Journal of The American Academy of Dermatology” In this study, researchers found that severe androgenic alopecia in hospitalized men was associated with a higher likelihood of testing positive for COVID-19.
18 citations
,
July 2020 in “Basic and Clinical Andrology” This article discusses concerns and recommendations from a French-speaking andrology society regarding COVID-19's potential impact on men's reproductive health and calls for further research in this area.
119 citations
,
May 2020 in “Journal of The American Academy of Dermatology” This study observed a high prevalence of androgenetic alopecia in patients hospitalized with severe COVID-19, with 79% of men and 42% of women affected, suggesting a potential link between androgen sensitivity and COVID-19 severity.
