Defining Compartmentalized Stem Cell Populations with Distinct Cell Division Dynamics in the Ocular Surface Epithelium

November 2020 in “ Development ”

Ryutaro Ishii, Hiromi Yanagisawa, Aiko Sada

Studysummary This study found that the ocular surface epithelium in mice contains distinct stem cell populations with unique cell division dynamics that change behaviorally in response to different levels of injury.

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research Glutamate Transporter SLC1A3 Mediates Inter-Niche Stem Cell Activation During Skin Growth

34 citations , April 2018 in “EMBO journal”

This study found that in mouse skin, the activation of stem/progenitor cells is synchronized across different niches during growth, with the glutamate transporter SLC1A3 playing a crucial role in this process.

research Homeostasis, Regeneration, And Tumor Formation In The Mammalian Epidermis

44 citations , January 2018 in “The International Journal of Developmental Biology”

This review discusses the role and plasticity of epidermal stem cells in skin maintenance, wound repair, and cancer, noting recent insights from advanced technologies but providing no new clinical results.

Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

research Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

54 citations , January 2016 in “Cell reports”

This study found that different epidermal stem cell populations contribute to the formation of various skin tumors and new hair follicles following β-catenin activation in the adult epidermis.

research Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration

305 citations , June 2012 in “Nature”

This study reports that hair regeneration in live mice involves spatially regulated stem cell divisions and requires mesenchymal interactions, observed in real-time using a novel non-invasive imaging method.

research Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis

421 citations , September 2003 in “Development”

This study concluded that label-retaining cells in mouse epidermis differ in their sensitivity to proliferative stimuli, influencing their division and potential transdifferentiation without consistently depleting their population.