Efficacy of Oral Spironolactone in the Treatment of Androgenetic Alopecia in Female Patients: A Case Series of 11 Patients

    January 2025
    Lina Benchekroun, Hanane Darghal, Lina Mouline, Nadia Ismaïli, Laïla Benzekri, Mariame Meziane
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    TLDR Spironolactone is generally safe and effective for treating hair loss in women, but may be less effective in severe cases.
    This case series evaluated the efficacy and safety of oral spironolactone in 11 female patients with androgenetic alopecia (AGA). Patients were treated with spironolactone at doses of 25 mg to 100 mg daily, in combination with other therapies such as topical minoxidil and platelet-rich plasma, over 6 to 36 months. Ten patients showed a one-grade improvement on the Sinclair scale, while one patient with severe AGA did not respond, likely due to poor adherence. The treatment was generally well tolerated, with mild side effects like mastodynia and menstrual irregularities. The study suggests spironolactone is a safe and effective treatment for female AGA, though its efficacy may be limited in advanced cases, and further large-scale trials are needed.
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      community Comparison of options: topical vs medication

      in Female  1 upvotes 1 year ago
      A user diagnosed with AGA is seeking advice on hair loss treatments, comparing topical Minoxidil, Spironolactone, and Finasteride to oral medications and natural methods like dermastamping, PRP, and LED light. They are concerned about side effects and effectiveness, especially given their existing fatigue.

      community Dutasteride 2 years 3 month results

      in Finasteride/Dutasteride  251 upvotes 2 years ago
      The user tried dutasteride for hair loss for 2.5 years but experienced drastic thinning and receding hairline. They decided to switch back to finasteride, along with minoxidil, LLLT, and ketoconazole, due to dissatisfaction with dutasteride's results and side effects.

      community What kind of pill should i choose?

      in Female  6 upvotes 6 years ago
      Treating alopecia androgenetica with limited options, such as spironolacton, dutasteride, finasteride, minoxidil 5%, Rogaine foam for men, a shampoo with ketoconazol, iron supplement and dermarolling.

      community Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs

      in Research/Science  3 upvotes 2 years ago
      The review discusses traditional hair loss treatments like minoxidil and finasteride, and newer options like Low-Level Laser Therapy, microneedling, and platelet-rich plasma for androgenetic alopecia. It highlights the need for more high-quality trials to assess these treatments' effectiveness and standardized protocols for emerging therapies.

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