From Evidence to Practice: Insights from the Multidisciplinary Team on the Optimal Integration of GLP-1 Receptor Agonists in Obesity Management Services

    August 2024 in “ Nutrition Bulletin ”
    Adrian Brown, Duane Mellor, Janine Makaronidis, Emma Shuttlewood, Alexander D. Miras, Dimitri J. Pournaras
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    TLDR GLP-1 receptor agonists help with weight loss but need to be combined with other treatments for best results.
    The document highlights the integration of GLP-1 receptor agonists (GLP-1 RAs) in obesity management, noting their significant weight loss benefits demonstrated in trials like STEP-1 and SURMOUNT, with up to 22.5% weight loss. It emphasizes the need for a holistic approach that combines GLP-1 RAs with dietary, behavioral, and possibly surgical treatments, while addressing challenges such as side effects, long-term weight maintenance, and psychological impacts. The document calls for better psychological support, real-world data, and individualized approaches to optimize care, and stresses the importance of monitoring for nutritional deficiencies and muscle loss. Multimodal treatment strategies and addressing weight stigma are crucial for effective long-term management.
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