'Omics' Approaches for Studying the Microbiome in Alopecia Areata

    September 2020 in “ Journal of Investigative Medicine ”
    Daniela Pinto, Anna Trink, Elisabetta Sorbellini, Giammaria Giuliani, Fabio Rinaldi
    Image of study
    TLDR Omics techniques are needed to understand the scalp microbiome's role in alopecia areata for new treatments.
    The document from October 2020 discusses the significance of 'omics' approaches, like metagenomics and metabolomics, in studying the microbiome's role in alopecia areata (AA), a type of hair loss involving the immune system. It highlights that microbial dysbiosis, particularly involving Propionibacterium and Staphylococcus, has been observed in AA. The authors argue that these techniques can elucidate the microbiota composition changes and their effects on biological mechanisms in AA. They also point out the potential of omics in creating targeted therapies, including "postbiotical" drugs. The conclusion is that while the scalp microbiome's taxonomic composition in AA has been explored, the functional implications require more research through omics to develop new therapeutic strategies.
    Discuss this study in the Community →

    Research cited in this study

    12 / 12 results

    Related Community Posts Join

    6 / 1000+ results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 4 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The link between hair loss and gut health

      in Research/Science  59 upvotes 4 years ago
      The conversation discusses the potential link between gut health and hair loss, with personal experiences of hair thinning and stomach issues shared. Some individuals found no success with common hair loss treatments like Minoxidil and Finasteride and are exploring the impact of gut health on hair growth.

      community Alopecia Areata Question

      in Treatment  2 upvotes 3 years ago
      A user with alopecia totalis, borderline universalis, seeks advice on getting into a Xeljanz trial or appealing insurance for coverage. They experienced significant hair regrowth but are now seeing hair loss again and want to try Xeljanz.

      community mbp alopecia areata or vitamin deficiency

      in Chat 6 months ago
      A 19-year-old male has been using topical finasteride and minoxidil for 8 months with no progress and is considering seeking a second opinion due to potential misdiagnosis. The discussion revolves around whether the hair loss is due to male pattern baldness, alopecia areata, or a vitamin deficiency.

      community Olumiant alternative for Alopecia Areata?

      in Treatment  1 upvotes 1 year ago
      A user with alopecia areata is considering treatment options like injections or Olumiant but is concerned about cost and whether delaying treatment will lead to permanent hair loss. They are seeking alternative treatments that are more affordable for a college student.

    Related Research

    1 / 1 results