TLDR Olumiant® (Baricitinib) is effective for treating hair loss from Alopecia Areata.
The document discusses the results of two Phase 3 trials of Baricitinib, a Janus Kinase inhibitor, for the treatment of Alopecia Areata. The trials involved a significant number of participants, although the exact number is not specified in the document. The results showed that Baricitinib was effective in treating Alopecia Areata, a condition characterized by hair loss. The drug, marketed as Olumiant®, was subsequently approved for this use. The study was conducted by a team of researchers, including King B, Ohyama M, Kwon O, Zlotogorski A, Ko J, Mesinkovska NA, Hordinsky M, Dutronc Y, Wu WS, McCollam J, Chiasserini C, Yu G, Stanley S, Holzwarth K, DeLozier AM, Sinclair R, and the BRAVE-AA Investigators.View this study on pubmed.ncbi.nlm.nih.gov →
Tofacitinib can temporarily improve hair growth in alopecia universalis, but its effectiveness may decrease over time.
Oral and topical tofacitinib can help regrow hair in people with severe alopecia areata.
Tofacitinib 2% ointment helped hair regrow in 3 out of 10 patients with alopecia areata, but caused side effects like scalp irritation and raised cholesterol in some.