Oral Janus Kinase Inhibitors for the Treatment of Alopecia Areata: A Systematic Review and Meta-Analysis

    January 2019 in “ 프로그램북(구 초록집) ”
    Ye Eun Kim, Ohsang Kwon, Hyun Sun Park
    TLDR Both tofacitinib and ruxolitinib are effective and tolerable for treating alopecia areata.
    This systematic review and meta-analysis investigated the efficacy and adverse events of oral Janus kinase (JAK) inhibitors in treating alopecia areata (AA). Analyzing 321 cases from 12 studies, the overall rate of achieving more than 50% hair regrowth (SALT50) was 66%. Ruxolitinib showed a higher response rate (79%) compared to tofacitinib (62%), though the difference was not statistically significant. Infections were the most common adverse events, with ruxolitinib having fewer adverse events (28%) than tofacitinib (35.2%). The study concluded that both tofacitinib and ruxolitinib were effective and tolerable for AA treatment, but emphasized the need for further randomized controlled trials with long-term follow-up.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community What else is good. Besides the big 3.

      in Chat  36 upvotes 6 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community 8 months apart on the mother of all stacks

      in Progress Pictures  149 upvotes 1 year ago
      User Tricky9555 tried various hair loss treatments for 8 months with no visible results. Others suggested considering a hair transplant, checking thyroid levels, and being patient for up to 24 months for potential results.
      Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

      in Research  865 upvotes 5 months ago
      The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

      community 8 months Oral min and Dutasteride

      in Progress Pictures  62 upvotes 6 days ago
      Oral minoxidil and dutasteride are used for hair loss with mixed results. Some users report new growth, while others suggest scalp inflammation may be an issue.

      community Oral minoxidil and lowering the dose?

      in Minoxidil  1 upvotes 1 week ago
      The user is experiencing significant hair regrowth with 5 mg oral minoxidil and 1 mg finasteride but also side effects like eye puffiness and hypertrichosis. They are considering reducing the minoxidil dose to 2.5 mg to lessen side effects and are curious about caffeine serums for eye puffiness.

    Similar Research

    6 / 1000+ results