Evaluation of Olive Oil-Based Formulations Loaded with Baricitinib for Topical Treatment of Alopecia Areata

April 2025 in “ Pharmaceutics ”

Negar Beirampour, Mireia Mallandrich, Paola Bustos-Salgado, Valeri Domínguez-Villegas, Núria Garrós, Roya Mohammadi-Meyabadi, Beatriz Clares, María Nuria Romero Olid, Francisco J. Pérez‐Cano, Marina Girbal, Maria J. Rodríguez-Lagunas, Joaquim Suñer‐Carbó, Ana C. Calpena

Baricitinib alopecia areata olive oil-based formulations hair growth follicular regeneration antioxidant activity skin retention bioavailability BCT

TLDR Oil A formulation with Baricitinib shows promise for treating alopecia areata by promoting hair growth.

The study investigates olive oil-based formulations loaded with Baricitinib (BCT) for treating alopecia areata, focusing on three formulations with varying components. Oil A demonstrated the highest skin retention and bioavailability, making it the most promising candidate. The formulations showed stable physicochemical properties, effective antioxidant activity, and favorable release and permeation profiles. In vivo tests on mice indicated that these formulations, particularly Oil A, could promote hair growth and follicular regeneration. The study suggests these formulations, especially Oil A, warrant further clinical evaluation as potential treatments for alopecia areata.

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Research cited in this study

11 / 11 results

research Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions

4 citations, November 2023 in “Frontiers in immunology”

New treatments targeting T-cell pathways are needed for better alopecia areata management.

research Efficacy and Safety of Baricitinib in Patients With Alopecia Areata: Evidence to Date

September 2023 in “Drugs in context”

Baricitinib is a promising treatment for alopecia areata.

research Novel Potential Therapeutic Targets of Alopecia Areata

1 citations, April 2023 in “Frontiers in Immunology”

New treatments for hair loss from alopecia areata may include targeting immune cells, using stem cells, balancing gut bacteria, applying fatty acids, and using JAK inhibitors.

research Treatment of Severe Alopecia Areata with Baricitinib

25 citations, October 2019 in “JAAD Case Reports”

Baricitinib helped a woman with severe hair loss regrow almost all her hair without side effects.

research Pathomechanisms of Immune-Mediated Alopecia

45 citations, April 2019 in “International Immunology”

The study concluded that immune cells attacking hair follicles cause hair loss in alopecia, with genetics and environment also playing a role, and highlighted the potential of certain treatments.

research Alopecia Areata: Overview and Insights from January 2018

290 citations, December 2017 in “Journal of The American Academy of Dermatology”

Alopecia areata is an autoimmune condition causing hair loss, influenced by genetics, stress, and diet, and may be prevented by a high soy oil diet.

research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

184 citations, February 2015 in “EBioMedicine”

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

research The Autoimmune Basis of Alopecia Areata: A Comprehensive Review

162 citations, October 2014 in “Autoimmunity reviews”

Alopecia areata is caused by the immune system attacking hair follicles.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations, August 2014 in “Nature medicine”

Alopecia areata can be reversed by JAK inhibitors, promoting hair regrowth.

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

185 citations, June 2014 in “Journal of Investigative Dermatology”

A man with severe hair loss and skin disease regrew his hair with no side effects after taking tofacitinib.

research The Histopathology of Alopecia Areata in Vertical and Horizontal Sections

19 citations, December 2001 in “Dermatologic Therapy”

Horizontal scalp biopsy sections are better for diagnosing alopecia areata, showing fewer hair follicles and more miniaturized hairs.

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research Twenty Nail Dystrophy with Alopecia Areata in an Atopic Child

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A child with rough nails also had hair loss and allergies.

Evaluation of Olive Oil-Based Formulations Loaded with Baricitinib for Topical Treatment of Alopecia Areata

Research cited in this study

research Inhibition of T-Cell Activity in Alopecia Areata: Recent Developments and New Directions

research Efficacy and Safety of Baricitinib in Patients With Alopecia Areata: Evidence to Date

research Novel Potential Therapeutic Targets of Alopecia Areata

research Treatment of Severe Alopecia Areata with Baricitinib

research Pathomechanisms of Immune-Mediated Alopecia

research Alopecia Areata: Overview and Insights from January 2018

research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

research The Autoimmune Basis of Alopecia Areata: A Comprehensive Review

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

research Killing Two Birds with One Stone: Oral Tofacitinib Reverses Alopecia Universalis in a Patient with Plaque Psoriasis

research The Histopathology of Alopecia Areata in Vertical and Horizontal Sections

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