Nutrients Regulation of Skin Cells From Canines and Cats Via Wnt/β-Catenin Signaling Pathway

February 2025 in “ Frontiers in Veterinary Science ”

Xue Sun, Yan Ma, Yuan Gao, Jia Liu, Yunliang Li, Lei Lv

The study highlights the importance of the Wnt/β-catenin signaling pathway in hair regeneration for pets, specifically canines and cats. It identifies keratin hydrolyzed, egg yolk lecithin, and fish collagen peptide as nutrients that promote β-catenin nuclear translocation and enhance the expression of target genes in skin cell lines. These findings suggest that these nutrients could be beneficial in promoting hair regeneration and addressing hair loss in pets, which is crucial for their overall health and appearance.

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research Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/Beta-Catenin and BMP Signaling Pathways

October 2022 in “International Journal of Molecular Sciences”

Fish collagen peptides can significantly promote hair growth.

Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro

research Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro

5 citations, December 2021 in “Skin Pharmacology and Physiology”

Metformin helps lab-grown skin and hair cells work better to create hair.

research KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis

13 citations, March 2021 in “British Journal of Pharmacology”

KY19382 helps regrow hair and create new hair follicles.

research Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss

86 citations, July 2020 in “International Journal of Molecular Sciences”

Activating the Wnt/β-catenin pathway could lead to new hair loss treatments.

research Role of the Wnt Signaling Pathway in Keratoacanthoma

2 citations, November 2019 in “Cancer reports”

The Wnt signaling pathway is not a major factor in the development of keratoacanthoma, a type of skin tumor.

Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations, May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research Bald Thigh Syndrome in Sighthounds: Revisiting the Cause of a Well-Known Disease

5 citations, February 2019 in “PloS one”

Bald thigh syndrome in sighthounds is caused by structural defects in hair shafts due to downregulated genes and proteins.

research STAT5 Activation in the Dermal Papilla Is Important for Hair Follicle Growth Phase Induction

32 citations, April 2016 in “Journal of Investigative Dermatology”

STAT5 activation is crucial for starting the hair growth phase.

Coat Condition, Housing Condition, And Measurement Of Fecal Cortisol Metabolites: A Non-Invasive Study About Alopecia In Captive Rhesus Macaques (Macaca Mulatta)

research Coat Condition, Housing Condition, And Measurement Of Fecal Cortisol Metabolites: A Non-Invasive Study About Alopecia In Captive Rhesus Macaques (Macaca Mulatta)

51 citations, November 2005 in “Journal of Medical Primatology”

Alopecia in captive rhesus macaques is affected by season, sex, age, housing, and stress, with complex links between stress hormones and hair loss.