A Novel Hope for Alopecia Totalis Patients: Case Report

November 2020 in “ Dubai medical journal ”

Mohamed A. Elsayed, Laila Al Otaibi, Nael Quraishy, Afzalhussein Yusufali

alopecia totalis tofacitinib Janus kinase inhibitor JAK inhibitor hair regrowth AT

TLDR Tofacitinib may effectively regrow hair in alopecia totalis patients.

This case report described the treatment of a 24-year-old female patient with alopecia totalis (AT) using tofacitinib, a Janus kinase (JAK) inhibitor. The patient, who also had juvenile chronic arthritis, had not responded satisfactorily to other treatments over 3 years. She was administered tofacitinib 5 mg orally twice a day, resulting in noticeable hair regrowth starting from the 4th week and full regrowth by the 9th month, with no serious adverse effects. The findings suggested that tofacitinib could be an effective and well-tolerated treatment for AT, though larger studies were recommended to confirm its long-term efficacy.

View this study on karger.com →

Discuss this study in the Community →

Research cited in this study

3 / 3 results

research Sequential High- And Low-Dose Systemic Corticosteroid Therapy For Severe Childhood Alopecia Areata

18 citations, January 2017 in “Journal der Deutschen Dermatologischen Gesellschaft”

High and low doses of prednisolone helped 62% of children with severe alopecia regrow hair with some weight gain and mild acne as side effects.

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

238 citations, November 2016 in “Journal of The American Academy of Dermatology”

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

184 citations, February 2015 in “EBioMedicine”

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

Related Research

9 / 9 results

research Resistant Alopecia Areata Treated with Tofacitinib

1 citations, September 2022 in “International Journal of Trichology”

Tofacitinib can be effective in treating hair loss caused by alopecia areata.

Oral Tofacitinib and Systemic Corticosteroids, Alone or in Combination, in Patients With Moderate-to-Severe Alopecia Areata: A Retrospective Study

research Oral Tofacitinib and Systemic Corticosteroids, Alone or in Combination, in Patients With Moderate-to-Severe Alopecia Areata: A Retrospective Study

8 citations, June 2022 in “Frontiers in Medicine”

Both individual and combined treatments of tofacitinib and corticosteroids can help regrow hair in moderate-to-severe alopecia areata, but ongoing treatment may be necessary.

research Alopecia Areata Flare Patterns in Children and Young Adults on Systemic Tofacitinib

7 citations, March 2021 in “Journal of the American Academy of Dermatology”

Tofacitinib can regrow hair in alopecia areata patients, but some may experience flares during treatment.

research Experience with Oral Tofacitinib in Severe Alopecia Areata with Different Clinical Responses

11 citations, February 2021 in “Journal of Cosmetic Dermatology”

Oral tofacitinib helped regrow hair in over half of the patients with severe alopecia, but relapses and side effects were common.

research Tofacitinib Therapy for Children with Severe Alopecia Areata

39 citations, January 2019 in “Journal of the American Academy of Dermatology”

Tofacitinib may help treat severe childhood alopecia areata, but risks require careful consideration.

research Successful Treatment of Severe Alopecia Areata With Oral or Topical Tofacitinib

4 citations, July 2018 in “PubMed”

Oral and topical tofacitinib can help regrow hair in people with severe alopecia areata.

Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A Promising Therapy for the Treatment of Alopecia Areata: A Case Report of Six Patients

research Tofacitinib (Selective Janus Kinase Inhibitor 1 and 3): A Promising Therapy for the Treatment of Alopecia Areata: A Case Report of Six Patients

24 citations, January 2018 in “International Journal of Trichology”

Tofacitinib helped regrow hair in patients with alopecia, with few side effects.

research Treatment of Severe Alopecia Areata with the Oral Janus Kinase Inhibitor, Tofacitinib: A Retrospective Chart Review

1 citations, April 2017 in “Journal of Investigative Dermatology”

Tofacitinib may help regrow hair in severe alopecia areata, but results differ greatly between people.

research Excellent Response to Tofacitinib Treatment in a Patient with Alopecia Universalis

16 citations, January 2017 in “Acta dermatovenerologica Alpina, Pannonica et Adriatica (Tiskana izd.)”

A patient with complete hair loss regrew all her hair using tofacitinib.

A Novel Hope for Alopecia Totalis Patients: Case Report

Research cited in this study

research Sequential High- And Low-Dose Systemic Corticosteroid Therapy For Severe Childhood Alopecia Areata

research Tofacitinib for the Treatment of Severe Alopecia Areata and Variants: A Study of 90 Patients

research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

Related Community Posts Join

community Alopecia Areata Question

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

community Can I punch someone if they make fun of my hair loss, just like Will Smith did?

community This guy claims stem cells fixed his balding

community Shaving is NOT accepting baldness

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.