Faculty Opinions Recommendation of Identification of Novel Hair-Growth Inducers by Means of Connectivity Mapping

February 2010 in “ Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ”

Ralf Paus, Jennifer Elisabeth Klöpper

hair growth inducers gene expression cyclosporin A DNA microarray analysis melanin biosynthesis immune response cell proliferation hair-specific keratins connectivity map fluphenazine iloprost CsA Cmap

TLDR Fluphenazine and iloprost can induce hair growth.

The study demonstrated the use of the connectivity map (Cmap) as an innovative method to identify potential hair-growth inducers by analyzing gene expression profiles. Researchers compared gene expression patterns induced by cyclosporine A (CsA), a known hair growth promoter, with other compounds. They identified fluphenazine as a compound with similar gene expression effects to CsA, which successfully induced hair growth in mice. Additionally, iloprost showed potential when used in combination with fluphenazine. This research highlighted Cmap's utility in discovering new agents for hair growth by linking complex gene expression profiles to effective treatments.

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