Neural Crest Cells and Their Potential Therapeutic Applications

The document discussed the potential therapeutic applications of neural crest cells (NCC), which are multipotent cells capable of extensive migration and differentiation into various cell types. It compared NCC characteristics from embryonic, fetal, and adult tissues, and explored experimental strategies for deriving NCC from embryonic stem cells, induced pluripotent stem cells, and skin fibroblasts. The study highlighted the potential of these cells for clinical use in regenerative medicine, given their ability to differentiate into diverse cell types. It also noted that genetic mutations affecting NC development could lead to neurocristopathies, a group of congenital diseases. The identification and isolation of multipotent stem NCC from various sources were seen as promising for regenerative therapies.