TLDR Oral Acitretin effectively resolved symptoms in a child with Netherton syndrome.
Netherton syndrome (NS) is a rare genetic disorder characterized by ichthyosis linearis circumflexa, hair shaft abnormalities, and atopic diathesis. This case study discusses a 7-year-old boy with NS, presenting with itchy lesions and hair abnormalities, who showed complete resolution after 2 months of treatment with oral Acitretin. The study highlights the importance of considering NS in atopic children with similar symptoms. Diagnosis is supported by clinical features and can be confirmed through genetic testing for SPINK5 mutations. Treatment typically involves topical emollients, corticosteroids, and systemic options like retinoids.
9 citations
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December 2015 in “Journal of Dermatological Case Reports” Narrowband UVB therapy significantly improved a child's rare skin condition.
124 citations
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January 1995 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Netherton's syndrome is linked to high IgE levels and unique skin and hair symptoms, and may improve with ammonium lactate lotion and allergy management.
33 citations
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March 2006 in “Seminars in cutaneous medicine and surgery” The document explains how to identify different hair problems using a microscope.
59 citations
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June 2008 in “Journal of The American Academy of Dermatology” The article explains the genetic causes and symptoms of various hair disorders and highlights the need for more research to find treatments.
30 citations
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August 1983 in “Pediatric Clinics of North America” Most hair loss in children is caused by a few common conditions, and it's important to diagnose these properly and support the child's mental health.
26 citations
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July 2019 in “Dermatology and Therapy” The conclusion is that genetic testing is important for diagnosing and treating various genetic hair disorders.
