TLDR A 17-year-old with Netherton syndrome has dry, itchy skin, brittle hair, and high IgE levels, treated with antihistamines and emollients.
A 17-year-old Egyptian patient with Netherton syndrome presented with pruritic dry skin and short brittle hair since infancy. Born to healthy nonconsanguineous parents, he developed erythroderma and scaling at 4 weeks old, along with recurrent infections and failure to thrive in his first year. By age 2, his growth normalized, but he developed erythematous, scaly lesions. Despite these symptoms, he achieved normal developmental milestones and intelligence. Family history included eczema and allergic rhinitis but not ichthyotic disorders. Physical examination revealed scaly, hyperkeratotic lesions and sparse, brittle hair with bamboo hair characteristics. Elevated IgE levels were noted, and a skin biopsy confirmed the diagnosis. Treatment included antihistamines, emollients, and 10% urea.
124 citations
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January 1995 in “The journal of allergy and clinical immunology/Journal of allergy and clinical immunology/The journal of allergy and clinical immunology” Netherton's syndrome is linked to high IgE levels and unique skin and hair symptoms, and may improve with ammonium lactate lotion and allergy management.
1 citations
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26 citations
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July 2019 in “Dermatology and Therapy” The conclusion is that genetic testing is important for diagnosing and treating various genetic hair disorders.
126 citations
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January 1987 in “Journal of The American Academy of Dermatology” The document concludes that understanding hair structure is key to diagnosing hair abnormalities and recommends gentle hair care for management.
