Histopathological Correlates of NAFLD in PCOS: Correlation with Serum Creatinine, eGFR, and Urinary Albumin Levels

This study investigated the relationship between non-alcoholic fatty liver disease (NAFLD) and early renal dysfunction in 100 South Asian women with polycystic ovary syndrome (PCOS). NAFLD was found in 85% of participants, with most cases being Grade I. The study revealed that as NAFLD severity increased, there was a significant rise in serum creatinine and urinary albumin levels, and a decline in estimated glomerular filtration rate (eGFR). Strong correlations were observed between histopathological grading of NAFLD and renal function markers, suggesting that renal impairment may occur early in PCOS patients with NAFLD. The findings highlight the importance of integrating hepatic and renal screening for early detection and risk management in this population.