Cellular Response of Keratinocytes to the Entry and Accumulation of Nanoplastic Particles
April 2024
in “
Particle and Fibre Toxicology
”
keratinocytes nanoplastics stratum corneum 3D keratinocyte/dermal fibroblast co-culture transepidermal transport IL-17 signaling pathway myofibroblast α-smooth muscle actin pro-Collagen Ia skin inflammation immune responses skin cells plastic particles skin barrier skin model skin transport inflammatory pathway muscle actin collagen production skin irritation immune system
Studysummary In this study, researchers investigated the penetration and cellular responses to nanoplastics in human skin models with compromised barriers, finding that nanoplastics can penetrate the skin, accumulate in cells, and trigger inflammatory responses through specific signaling pathways.
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