Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Skin and Subcutaneous Tissue Diseases: Current Evidence from Clinical Trials

November 2025 in “ Eurasian journal of applied biotechnology ”

Aidar Dairov

mesenchymal stem cell-derived exosomes MSC-Exo alopecia skin and subcutaneous tissue diseases

TLDR Mesenchymal stem cell-derived exosomes show promise for treating skin and tissue diseases.

The document reviews 15 clinical trials on mesenchymal stem cell-derived exosomes (MSC-Exo) for treating skin and subcutaneous tissue diseases (SSTDs), with a focus on alopecia. These trials, conducted in countries like the United States and China, highlight the growing interest in MSC-Exo as a therapeutic option due to their promising properties. The trials have been increasing since 2022, with six completed and others in various stages of recruitment. The study underscores the potential of MSC-Exo in addressing SSTDs, supported by funding from the Republic of Kazakhstan.

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