Morphogenesis and Renewal of Hair Follicles from Adult Multipotent Stem Cells

    January 2001 in “Cell
    Hideo Oshima, Ariane Rochat, Cécile Kedzia, Koichi Kobayashi, Yann Barrandon
    TLDR Adult mouse skin contains stem cells that can create new hair, skin, and oil glands.
    The study from January 1, 2001, found that the upper region of the outer root sheath in adult mice's vibrissal follicles harbors multipotent stem cells capable of generating new hair follicles, sebaceous glands, and epidermis. These stem cells are responsive to morphogenetic signals, particularly during the cessation of hair production and structural changes in the follicle's lower region, where a significant number of clonogenic keratinocytes are present. The findings suggest that these keratinocytes are likely the same or closely related to the multipotent stem cells and that they migrate to the follicle's base to promote whisker growth. The study highlights the importance of precise control over stem cell trafficking for the regulation of hair growth.
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