In Vivo Evidence for an Increase in 5alpha-Reductase Activity in the Rat Central Nervous System Following Morphine Exposure

    September 2005 in “ International Journal of Developmental Neuroscience ”
    Hossein Amini, Abolhassan Ahmadiani
    TLDR Morphine increases testosterone breakdown in the rat brain and spinal cord.
    The study investigated the effects of morphine on testosterone levels in rats, revealing that both acute and chronic morphine exposure significantly reduced testosterone in the serum and central nervous system (CNS), particularly in the spinal cord and brain. The reduction was more pronounced in the CNS, suggesting increased local metabolism rather than just peripheral decline. This was supported by the finding that finasteride, a 5alpha-reductase inhibitor, blocked testosterone elimination in the CNS after morphine exposure. Additionally, chronic morphine exposure increased serum levels of 5alpha-reduced testosterone metabolites, which was not observed with finasteride co-treatment. The study concluded that morphine exposure increased CNS 5alpha-reductase activity, a key enzyme in testosterone metabolism.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 919 results

      community Finasteride vs Dutasteride: The Science

      in Research/Science  167 upvotes 2 years ago
      The conversation compares Finasteride and Dutasteride for hair loss treatment, discussing their effectiveness and side effects. Users share personal results and consider combining treatments like Dutasteride with RU58841.

      community Why is Kevin Mann (Haircafe) Hated?

      in Chat  62 upvotes 2 years ago
      Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      by nkrata in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community How does hair loss and recovery work?

      in Chat  12 upvotes 1 year ago
      Hair loss varies due to genetic sensitivity to DHT and other factors. Treatments discussed include finasteride, minoxidil, RU58841, and microneedling.

    Related Research

    5 / 5 results