Molecular Studies of Hutchinson-Gilford Progeria Syndrome

    May 2009 in “ OPAL (Open@LaTrobe) (La Trobe University) ”
    Hanna Sagelius
    Studysummary In this study, a transgenic mouse model suggested that suppressing the expression of the HGPS mutation may reverse disease symptoms, including skin abnormalities, supporting the potential for treatment development.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 4

    1. Epidermal Expression of the Truncated Prelamin A Causing Hutchinson-Gilford Progeria Syndrome: Effects on Keratinocytes, Hair, and Skin Human Molecular Genetics · 2008
    2. The Hair Cycle Journal of Cell Science · 2006
    3. Conditional Gene Expression in the Epidermis of Transgenic Mice Using the Tetracycline-Regulated Transactivators tTA and rTA Linked to the Keratin 5 Promoter Journal of Investigative Dermatology · 2000
    4. The Epidermis: Rising to the Surface Current opinion in genetics & development · 1994

    Related research 2

    1. Hutchinson-Gilford Progeria Syndrome - A Brief Introduction International Journal of Pharmacological Research · 2018
    2. Atypical Progeroid Syndrome Due to Heterozygous Missense LMNA Mutations ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2009