Mitochondria-Targeted Biophysical Priming of Autologous Biologics for Skin Regeneration and Wound Repair

This review explores the role of mitochondria in skin aging, photoaging, and chronic wounds, highlighting oxidative stress and impaired bioenergetics as key factors. It discusses the use of autologous biologics like platelet-rich plasma and mesenchymal stem cell-derived products for skin rejuvenation and wound repair, emphasizing their effects through mitochondrial mechanisms such as metabolic reprogramming and intercellular mitochondrial transfer. The review introduces the concept of mitochondria-targeted biophysical priming using modalities like photobiomodulation, ultrasound, and mechanical stimulation to enhance the efficacy of these biologics. It also addresses the regulatory considerations necessary for clinical application.