Compounded Hair Solutions and Foams Containing Minoxidil: Does the Color Change Impact Stability?

August 2023 in “ Scientia Pharmaceutica ”

Hudson Polonini, Carolina C V Silva

minoxidil alopecia TrichoSol TrichoFoam active pharmaceutical ingredient API Rogaine

TLDR Color changes in Minoxidil hair products do not affect their effectiveness.

The study "Compounded Hair Solutions and Foams Containing Minoxidil: Does the Color Change Impact Stability?" investigated the stability of Minoxidil, a first-line treatment for alopecia, in hair solutions and foams. The study found that the beyond-use dates (BUDs) for the hair solutions were 380 days for 7.0% Minoxidil in TrichoSolTM, 180 days for 7.0% Minoxidil in TrichoFoamTM, 150 days for 1.0% Minoxidil in TrichoSolTM, and 120 days for 1.0% Minoxidil in TrichoFoamTM. However, for the US market, the BUD for 7.0% Minoxidil in TrichoSolTM would be 180 days due to US Pharmacopeia regulations. The study also found that Minoxidil products change color over time, but this does not impact their effectiveness. The study concludes that color changes do not affect the active pharmaceutical ingredient (API) content, making them suitable for use.

View this study on mdpi.com →

Discuss this study in the Community →

Cited in this study

12 / 12 results

research Compatibility of Different Formulations in TrichoConcept Vehicles for Hair Treatments

February 2022 in “Scientia Pharmaceutica”

Different hair loss treatment ingredients work well with TrichoTech™ vehicles for 3 to 6 months, making them good for use in hair treatments.

research Oral Minoxidil Treatment for Hair Loss: A Review of Efficacy and Safety

59 citations , March 2021 in “Journal of The American Academy of Dermatology”

Oral minoxidil promotes hair growth but may cause side effects; needs monitoring.

research Female Androgenetic Alopecia: An Update on Diagnosis and Management

43 citations , February 2020 in “American Journal of Clinical Dermatology”

FAGA diagnosis uses blood tests and trichoscopy, with treatments like topical minoxidil, oral anti-androgens, and hormone-modulating drugs.

research Minoxidil And Its Use In Hair Disorders: A Review

117 citations , August 2019 in “Drug Design Development and Therapy”

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

research Off-Label Use of Topical Minoxidil in Alopecia: A Review

32 citations , April 2019 in “American Journal of Clinical Dermatology”

Minoxidil helps treat eyebrow thinning, monilethrix, early hair loss, and shortens chemo-related hair loss.

research Minoxidil in the Treatment of Androgenetic Alopecia

26 citations , September 2018 in “Dermatologic Therapy”

Minoxidil helps treat pattern hair loss in both men and women.

research Androgenetic Alopecia: An Update Of Treatment Options

110 citations , August 2016 in “Drugs”

Minoxidil is the only FDA-approved topical drug for treating male or female pattern hair loss, and other medications like finasteride and dutasteride can also increase hair growth.

research Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia

27 citations , May 2014 in “Dermatologic Therapy”

New test predicts if hair loss treatment will work.

research Minoxidil: Mechanisms of Action on Hair Growth

397 citations , February 2004 in “British Journal of Dermatology”

Minoxidil boosts hair growth by opening potassium channels and increasing cell activity.

research Hypertrichosis in Females Applying Minoxidil Topical Solution and in Normal Controls

63 citations , May 2003 in “Journal of The European Academy of Dermatology and Venereology”

Minoxidil use increases facial hair growth in females, more in older users.

research Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment

123 citations , February 2002 in “Journal of The American Academy of Dermatology”

Minoxidil can cause skin allergy; use alternative solvents or treatments if allergic.

research Changes in Hair Weight and Hair Count in Men with Androgenetic Alopecia After Application of 5% and 2% Topical Minoxidil, Placebo, or No Treatment

115 citations , November 1999 in “Journal of The American Academy of Dermatology”

Minoxidil increases hair weight and count temporarily in men with hair loss.

4 / 4 results

research Alopecia Areata Treated With Topical Minoxidil

16 citations , April 1984 in “Archives of Dermatology”

Topical minoxidil can help hair regrowth in alopecia areata patients, but maintaining the growth after stopping treatment is inconsistent.