Minoxidil increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity of cultured human dermal papilla cells from balding scalp
February 1999
in “Journal of Dermatological Science”
TLDR Minoxidil boosts enzymes that help hair growth.
The study found that minoxidil increases the activity of 17β-hydroxysteroid dehydrogenase and 5α-reductase in human dermal papilla cells from balding scalp. These enzymes are involved in the conversion of testosterone to dihydrotestosterone, which is known to contribute to hair loss. The study suggests that minoxidil may work by increasing the activity of these enzymes, leading to increased hair growth. The study was conducted on cultured human dermal papilla cells from balding scalp, and further research is needed to clarify the role of 5α-reductase in male pattern baldness and whether the effect of minoxidil on testosterone metabolism is related to its therapeutic effect.
View this study on linkinghub.elsevier.com →
Cited in this study
research The Therapeutic Use of Topical Minoxidil
Minoxidil effectively treats hair loss, with better results in women.
research Reversal of Baldness in Patient Receiving Minoxidil for Hypertension
Minoxidil helped bald patient regrow hair.
research MINOXIDIL IN RESISTANT HYPERTENSION
Minoxidil with propranolol and diuretics lowers blood pressure but causes fluid retention and hair growth.
Related
research Sisaipho Alopecia Areata Treated With Tofacitinib and Oral Minoxidil
A study explored the treatment of Sisaipho alopecia areata, a rare variant of AA characterized by hair loss on the top of the scalp while sparing the temporal and occipital areas, using tofacitinib and oral minoxidil. The combination of these treatments showed promise in managing this challenging condition, which typically presents as nonscarring hair loss and can be difficult to treat.
research A Survey of Patient Attitudes Towards Topical Minoxidil in the Treatment of Hair Loss
Patients generally have positive attitudes towards using topical Minoxidil for hair loss treatment.
research Androgen Receptor–Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia
Male pattern baldness is linked to higher levels of a certain receptor in the scalp, which leads to the shrinking of blood vessels and hair loss. Early treatment targeting this receptor could be more effective.
research Pharmacological therapeutics in androgenetic alopecia
research Minoxidil increases 17β-hydroxysteroid dehydrogenase and 5α-reductase activity of cultured human dermal papilla cells from balding scalp
Minoxidil boosts enzymes that help hair growth.
research CLINICAL UPDATES IN HAIR
Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.
research Drugs Affecting Hair Growth
Different hair growth phases affect how follicles respond to X-rays, and hormones like testosterone and dihydrotestosterone play a key role in baldness; transplanted hair can grow on bald scalp areas.