Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis
June 2005
in “Matrix Biology”
TLDR Minoxidil affects collagen-related genes, potentially helping treat fibrosis.
The study investigated the effects of minoxidil on gene expression of lysyl hydroxylases (LH) and collagen cross-linking, which are involved in fibrosis. The researchers found that minoxidil inhibited the expression of LH1, LH2b, and LH3, with the most significant effect on LH1. Minoxidil had the potential to decrease hydroxyallysine cross-link formation, which suggests that it could be used as an anti-fibrosis therapy. The study used fibroblast cultures from healthy dermis, subcutaneous fat, and keloid, and analyzed gene expression using quantitative real-time PCR.
View this study on sciencedirect.com →
Cited in this study
research Minimum Structural Requirements for Minoxidil Inhibition of Lysyl Hydroxylase in Cultured Fibroblasts
Minoxidil needs specific structure to block lysyl hydroxylase; exploring alternatives may keep benefits without this effect.
research Characterization of a Partial cDNA for Lysyl Hydroxylase from Human Skin Fibroblasts; Lysyl Hydroxylase mRNAs Are Regulated Differently by Minoxidil Derivatives and Hydralazine
Minoxidil decreases LH expression, while hydralazine has mixed effects on prolyl and lysyl hydroxylase activities.
research Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts
Minoxidil reduces lysine hydroxylase in skin cells.
research Suppression of fibroblast proliferation and lysyl hydroxylase activity by minoxidil.
Minoxidil slows fibroblast growth and collagen production, potentially treating keloids, hypertrophic scars, and connective tissue disorders.
research Effects of Minoxidil on Cultured Human Skin Fibroblasts
Minoxidil slows down skin cell growth and may help treat scars and skin conditions.
Related
research Minoxidil exerts different inhibitory effects on gene expression of lysyl hydroxylase 1, 2, and 3: Implications for collagen cross-linking and treatment of fibrosis
Minoxidil affects collagen-related genes, potentially helping treat fibrosis.