Supplementary Material for: Microinjury-Induced Tumor Necrosis Factor-Alpha Surge Stimulates Hair Regeneration in Mice

January 2023 in “ Figshare ”

William A. Boisvert

TNF-α tumor necrosis factor-alpha microneedle treatment Wnt proteins VEGF vascular endothelial growth factor epidermal injury hair follicle hair regeneration TNF-alpha microneedling

TLDR Minor skin injuries can boost hair growth by increasing TNF-α.

The study investigates the role of microinjury-induced TNF-α in hair regeneration using C57BL/6N mice. It was found that microneedle (MN) treatment, which causes minor epidermal injury, leads to a TNF-α surge that promotes hair growth. This was evidenced by increased Wnt proteins and VEGF expression, thickened epidermis, and longer hair follicle length in the MN-treated and plucking control groups. Conversely, the application of a TNF-α blocker slowed hair growth, highlighting TNF-α's crucial role in the hair regeneration process.

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