Methylenetetrahydrofolate reductase C677T mutation in patients with alopecia areata in Turkish population

The study investigated the association between the MTHFR gene C677T mutation and alopecia areata (AA) susceptibility in the Turkish population, including 136 AA patients and 130 healthy controls. Using PCR-based RFLP assay, significant differences in genotype and allele frequencies of the MTHFR C677T mutation were found between AA patients and controls (p = 0.036 and p = 0.011, respectively). The CT + TT genotypes and T allele were identified as susceptibility factors for AA (p = 0.012). The findings suggested that the MTHFR C677T mutation might influence the risk of AA in the Turkish population, marking the first study to report this association.