Mon-323 Metastatic Adrenocortical Carcinoma Presenting With Mixed Cushing's And Virilization Syndrome Along With Bilateral Pulmonary Emboli

    April 2019 in “ Journal of the Endocrine Society ”
    Johnathon Seth Parham, Samantha E. Adamson, Richard E. Ostlund
    TLDR Rapid virilization should be checked for possible ovarian or adrenal cancer.
    A 57-year-old woman with a history of hypertension and hysterectomy presented with symptoms including shortness of breath, male pattern balding, and body hair growth, which were linked to metastatic adrenocortical carcinoma. Imaging revealed pulmonary emboli, multiple pulmonary nodules, and a large retroperitoneal mass. Biochemical tests showed elevated cortisol and testosterone levels, with undetectable ACTH, indicating hormone-secreting tumors. A biopsy confirmed metastatic adrenocortical carcinoma, and further scans showed widespread metastasis. The patient began treatment with mitotane, cisplatin, doxorubicin, and etoposide. The case highlighted that rapid virilization should prompt evaluation for potential ovarian or adrenal malignancies.
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