Comparison Between Melatonin Versus Melatonin and Photobiomodulation Versus Photobiomodulation in the Treatment of Alopecia X in German Spitz Dogs: Clinical, Randomized, Double-Blind, Parallel, Non-Inferiority Protocol

This study investigates the effectiveness of melatonin, photobiomodulation (PBM), and their combination in treating alopecia X in German Spitz dogs. Sixty dogs were divided into three groups: melatonin, PBM, and PBM + melatonin, with each group containing 20 dogs. The primary outcome was hair regrowth, assessed by follicle density, while secondary outcomes included hair thickness over a 90-day period. The study aims to determine if PBM can promote hair regrowth, with data analyzed using repeated measures ANOVA and significance set at p < 0.05.