Do Medications for Benign Prostate Syndrome Affect Mood or Cognition?

    February 2019 in “ Der Urologe ”
    Klaus Becher, Stephan Madersbacher, Martin C. Michel
    TLDR Medications for benign prostatic syndrome can cause cognitive issues and depression.
    The document examined the central nervous side effects of medications for benign prostatic syndrome (BPS), highlighting cognitive impairments and depressive symptoms. It found that muscarinic antagonists were associated with cognitive impairments, though the frequency varied. Depressive symptoms were consistently linked to 5α-reductase inhibitors like dutasteride and finasteride, with a plausible mechanism. A single study noted a moderate increase in dementia diagnoses with tamsulosin, but not with other α1-adrenoceptor antagonists, possibly due to selection bias. The document recommended that physicians monitor for these side effects during BPS treatment.
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