TLDR Maternal hypothyroidism harms skin development in rat offspring.
This study investigated the effects of maternal thyroid dysfunction on the skin development of rat offspring. Female Albino Oxfords rats were given an antithyroid substance to induce subclinical and overt hypothyroidism during pregnancy and lactation. Skin samples from male pups were analyzed within 24 hours and 7 days after birth. The study found that both forms of maternal hypothyroidism caused significant epidermal damage in pups, including pronounced hyperkeratosis, reduced germinal layer, and fewer hair follicles with delayed morphogenesis. The damage was more severe in pups from mothers with overt hypothyroidism, while those with subclinical hypothyroidism showed less pronounced and delayed impairments.
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