Follistatin Promotes LIN28B-Mediated Supporting Cell Reprogramming and Hair Cell Regeneration in the Murine Cochlea

February 2022 in “ Science Advances ”

Xiao‐Jun Li, C. Lloyd Morgan, Loyal A. Goff, Angelika Doetzlhofer

Follistatin LIN28B hair cell regeneration cochlear supporting cells transforming growth factor–β TGF-β–type signaling progenitor-like cells FST TGF-β

Studysummary This study found that coactivating LIN28B and follistatin enhances cochlear supporting cells' ability to regenerate hair cells in neonatal mice by reprogramming them into progenitor-like cells.

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