Generation of Bioengineered Feather Buds on Reconstructed Chick Skin from Dissociated Epithelial and Mesenchymal Cells

March 2016 in “ Development Growth & Differentiation ”

Kentaro Ishida, Toshiyuki Mitsui

epithelial cells mesenchymal cells chorioallantoic membrane epithelial-mesenchymal interactions FGF signaling Wnt/β-catenin signaling Notch signaling BMP signaling cutaneous appendages

Studysummary This study developed a bioengineering method to reconstruct embryonic dorsal skin from dissociated chick skin cells, allowing feather buds to form and grow in vitro, influenced by epithelial-mesenchymal interactions.

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This study found that FGF signaling is necessary for the initiation of feather placode development in chicken embryos, with FGF10 being implicated as an early dermal signal in the process.