Lupus Panniculitis as an Initial Manifestation of Systemic Lupus Erythematosus: A Case Report

August 2019 in “ Blucher Medical Proceedings ”

MÔNICA MÂNICA, Gustavo Nogueira, Luana Cocco Garlet, ANDREIA SILVA ROSA, ALESSANDRA PANOSSO SCHAFER, Emanuela Lando, GUILHERME CASA, CAROLINA BRIZOLA, Julia Bianchi, HENRIQUE ZIELKE, Bruna Dambrós Neckel, MOARA ALDROVANDI, Daniela Ragnini, M Pedro Magalhães, Carolina Silva, FRANCIELI PARIZOTTO, GUILHERME CENTENARO, Thaís Rohde Pavan

Systemic Lupus Erythematosus SLE Lupus Panniculitis LP Chronic Cutaneous Lupus Erythematosus CCLE Discoid Lupus Erythematosus T-lymphocyte autoimmune response panniculitis lymphocytic infiltrate dermis-epidermal junction Lupus Chronic Lupus Discoid Lupus T-cell immune response skin inflammation

TLDR Lupus Panniculitis can be an early sign of Systemic Lupus Erythematosus.

Systemic Lupus Erythematosus (SLE) is a chronic inflammatory disease that often involves the skin, leading to its inclusion in the diagnostic criteria. Lupus Panniculitis (LP), a rare form of Chronic Cutaneous Lupus Erythematosus (CCLE), affects 1-3% of patients and can occur alone or with SLE or Discoid Lupus Erythematosus. LP is characterized by a T-lymphocyte-mediated autoimmune response, with histopathological studies showing lobular or mixed panniculitis and a significant lymphocytic infiltrate at the dermis-epidermal junction.

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