Lupus Panniculitis as an Initial Manifestation of Systemic Lupus Erythematosus

April 2016 in “ Medicine ”

Yu‐Kun Zhao, Fang Wang, Wen-Na Chen, Rui Xu, Sheng Wang, Yuan-Wen Jiang, Di‐Qing Luo, Jiande Han

Lupus erythematosus panniculitis systemic lupus erythematosus methylprednisolone hair loss polyarthritis histopathology LEP SLE steroid treatment

TLDR Early treatment and regular check-ups are crucial for lupus patients to prevent progression and improve outcomes.

The document discussed lupus panniculitis as an initial manifestation of systemic lupus erythematosus (SLE), emphasizing the importance of early recognition for effective management. It presented a case report of a 19-year-old male who initially had lupus erythematosus panniculitis (LEP) with nodules and ulcers, which improved with methylprednisolone but recurred with additional symptoms like fever, hair loss, and polyarthritis. Blood tests showed leucopenia, positive antinuclear and Smith antibodies, and proteinuria. Histopathology confirmed LEP, and treatment with methylprednisolone and cyclophosphamide led to improvement. The report highlighted the need for regular follow-ups and early diagnosis to improve prognosis.

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