Lrig1 Expression Confers Suppressive Function to CD4+ Cells and Is Essential for Averting Autoimmunity via the Smad2/3/Foxp3 Axis

    September 2023 in “ Nature Communications ”
    Jae‐Seung Moon, Chun-Chang Ho, Jong‐Hyun Park … Sang‐Kyou Lee
    Studysummary In this study, researchers found that the cell surface protein Lrig1 plays a crucial role in regulating the suppressive function of regulatory T cells, suggesting it as a potential target for treating autoimmune diseases, as evidenced by experiments in mouse models.
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    Research cited in this study 1

    1. Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases Cell · 2020