Decreased Gas6 and sAxl Plasma Levels Are Associated with Hair Loss in COVID-19 Survivors

    March 2023 in “ International Journal of Molecular Sciences ”
    Daria Apostolo, Davide D’Onghia, Stelvio Tonello, Rosalba Minisini, Alessio Baricich, Carla Gramaglia, Filippo Patrucco, Patrizia Zeppegno, Antonio Acquaviva, Piero Emilio Balbo, Luigi Mario Castello, Giuseppe Cappellano, Annalisa Chiocchetti, Chiara Gerevini, Mara Giordano, Fatiha Laaguid, Marcello Manfredi, Davide Raineri, Cristina Rigamonti, Roberta Rolla, Valentina Romano, Marco Confalonieri, Paola Savoia, Elisa Zavattaro, Mario Pirisi, Barbara Ruaro, Pier Paolo Sainaghi, Mattia Bellan
    TLDR Lower Gas6 and sAxl levels are linked to hair loss in COVID-19 survivors.
    This study evaluated 263 COVID-19 survivors one year after hospital discharge to explore the link between plasma levels of Growth Arrest-Specific 6 (Gas6) and its soluble receptor Axl (sAxl) with hair loss. It found that 26.2% of participants experienced hair loss, which was associated with decreased levels of Gas6 and sAxl, particularly in females. Logistic regression analysis confirmed these biomarkers as independent predictors of hair loss. While most cases resolved spontaneously, 23.7% reported persistent hair loss after one year. The study suggested that alterations in the Gas6/sAxl pathway might contribute to post-COVID-19 hair loss, although the mechanisms were not fully understood.
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