Comparative Ubiquitinomics of Human Skin Reveals Insulin Receptor Ubiquitination as a Regulator of Collagen Secretion

    December 2025
    Joseph Inns, Andrew Michael Frey, Ishier Raote … Neil Rajan
    Studysummary In this study, researchers explored ubiquitination patterns in healthy human skin and CYLD cutaneous syndrome tumors, identifying extensive ubiquitin sites and differential protein ubiquitination linked to tumor pathology, highlighting the role of ubiquitination in tissue architecture and disease mechanisms.
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    Research cited in this study 1

    1. Cylindroma as a Tumor of Hair Follicle Origin Journal of Investigative Dermatology · 2006