research Comparative Ubiquitinomics of Human Skin Reveals Insulin Receptor Ubiquitination as a Regulator of Collagen Secretion
Ubiquitination of the insulin receptor regulates collagen secretion in human skin.
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research Smad7-Induced Beta-Catenin Degradation Alters Epidermal Appendage Development
Too much Smad7 changes skin and hair development by breaking down a protein called β-catenin, leading to more oil glands and fewer hair follicles.
research The Role of R-Spondins and Their Receptors in Bone Metabolism
R-spondins and their receptors help increase bone growth and may be used to treat bone loss diseases.
research A WWP2–PTEN–KLF5 Signaling Axis Regulates Odontoblast Differentiation and Dentinogenesis in Mice
WWP2 is crucial for tooth development in mice.
research NEDD4 and NEDD4L Regulate Wnt Signaling and Intestinal Stem Cell Priming by Degrading LGR5 Receptor
NEDD4 and NEDD4L help control intestinal stem cells and prevent tumors by breaking down the LGR5 receptor.
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5 / 18 resultscommunity GT20029 China Phase II Trial For AGA Reached Primary Endpoint
The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.
community PYRILUTAMIDE PHASE 3 RESULTS : No statistical significance
The phase 3 trial results for Pyrilutamide showed no significant difference from the control treatment in increasing hair count, leading to the company halting its development. Users discussed their disappointment and skepticism about hair loss treatments, with some mentioning other treatments like Minoxidil, Finasteride, and RU58841.
community Peptides that Stop Hair Loss? | In-depth Literature Review Video
Peptides like TB500, KPV, GHK-CU, and BPC-157 are overhyped for hair growth with limited proven effectiveness in humans. Combining peptides with delivery methods like iontophoresis and sonophoresis shows promise, but many claims remain unproven.
community hair loss treatment alternatives and ideas to improve gain
The post discusses using finasteride, minoxidil, ketoconazole, and a dermaroller for hair loss, along with spearmint capsules, pueraria mirifica, saw palmetto, biotin, and vitamins. The user is also considering microdosing finasteride with trans treatment and mentions the potential of herbal enemas and hair systems.
community How many mgs of zinc should I take while taking fin? I want to potentially offset side effects but not ruin the effectiveness of fin. I take .5 mg fin daily
A user asks about the appropriate zinc dosage to offset side effects while taking 0.5 mg of finasteride daily. Responses suggest zinc has a minor effect on hormones compared to finasteride.