research CYLD Cutaneous Syndrome Tumors Demonstrate Increased NF-kB Signaling and Diminished Collagen Organization
Skin tumors with CYLD cutaneous syndrome show more NF-κB activity and less organized collagen.
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research Tumor Mapping in Two Large Multigenerational Families With CYLD Mutations
CYLD mutations cause a variety of skin tumors with symptoms starting around age 16, and treatments are currently limited.
research Ubiquitomics of CYLD-Deficient Skin Tumors Reveals Dysregulation of Hair Follicle Keratinocyte Processes
CYLD deficiency in skin tumors disrupts hair follicle cell processes and protein secretion.
research Molecular Pathology of Skin Adnexal Tumors
New markers and pathways have been found in skin tumors, helping better understand and diagnose them.
research Coinheritance of BRCA2 and CYLD Germline Pathogenic Variants Associated with Targetable Metastatic Malignant Cylindroma
Coinheritance of BRCA2 and CYLD genes may lead to new treatment options for certain cancers.
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