Potential Lipolytic Effect of Panduratin A Loaded Microspicule Serum as a Transdermal Delivery Approach for Subcutaneous Fat Reduction

The study investigated the anti-adipogenesis and lipolysis effects of panduratin A from Boesenbergia rotunda extract, specifically in the form of a microspicule (MS) serum for transdermal delivery. The BP-3 extract, containing 0.29 g of panduratin A per g, demonstrated strong antiadipogenesis and lipolysis effects at concentrations below 10 µg/mL without being toxic to 3T3-L1 preadipocyte cells. When applied to the human thigh for 14 days, the MS serum reduced thigh circumference and improved skin hydration and firmness, with only mild skin erythema observed. The findings suggest that BP-3 extract in MS serum could be an effective lipolytic product for reducing subcutaneous fat.