Linear Immunoglobulin A/Immunoglobulin G Bullous Dermatosis Associated with Vogt-Koyanagi-Harada Disease

    May 2011 in “ The Journal of Dermatology ”
    Shigeto Yanagihara, Hiromi Kobayashi, Akiko Naruse, Chiharu Tateishi, Daisuke Tsuruta, Masamitsu Ishii
    TLDR A man had two rare autoimmune diseases that might be connected.
    A 35-year-old Japanese male was reported to have both linear IgA/IgG bullous dermatosis (LAGBD) and Vogt–Koyanagi–Harada disease, which is characterized by bilateral uveitis, vitiligo, alopecia, poliosis, and dysacousia. His human leukocyte antigen typing included −A24, B52, C*1202, DR*1502, and DQ*0601. Immunoblotting showed that his sera reacted to 180- and 230-kDa proteins at both IgA and IgG levels. The coexistence of these diseases might be linked through a shared autoimmune pathomechanism, although coincidence cannot be ruled out.
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