Development and Optimization of Levofloxacin In-Situ Emulgel to Manage Ocular Bacterial Infections
February 2025
in “
Notulae Scientia Biologicae
”
Studysummary In this study, researchers developed an in-situ gel formulation of antibacterial Levofloxacin for the eye, which showed prolonged drug release, increased residence time, and effective antibacterial action, suggesting it may be a safe and effective ocular delivery system for antibiotics.
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The study focused on developing and optimizing an in-situ emulgel containing Levofloxacin for managing ocular bacterial infections. Traditional eye drops often have poor bioavailability due to the eye's natural barriers, prompting the need for improved delivery systems. The researchers prepared various emulgels using different gelling agents and optimized them based on gelation time and capacity. Formulations F5, F9, F10, and F11 were identified as optimal, demonstrating prolonged drug release, enhanced residence time, and effective antibacterial action. These formulations were found to be biocompatible, suggesting they are safe and effective, and could potentially be used for delivering other antibiotics.
